Pseudomonas is a genus of gram-negative bacteria. It belongs to the family Pseudomonadaceae and is in the class Gammaproteobacteria. Not all strains of this type of bacteria cause infection, but some ...

Whilst the ultimate outcome of the lytic cycle is production of new phage progeny and death of the host bacterial cell, this is a multistep process involving precise coordination of gene transcription ...

本研究针对囊性纤维化患者中耐药铜绿假单胞菌感染问题，开展噬菌体疗法研究，成功分离并鉴定新型噬菌体PSA-KC1，其对68%的耐药菌株有效，有望成为安全的治疗候选方案，为抗生素耐药性挑战提供新思路。 囊性纤维化（Cystic Fibrosis, CF）是一种常见的遗传性 ...

Because phages exert pressure on the bacteria they infect and some phage genomes encode virulence factors and toxins, a role for specific phages or communities of phages in human health seems ...

Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China Shenzhen Research Institute, City University of Hong Kong, Shenzhen, China Tung Research Centre, City University of ...

Methods: In this work, we studied the Pseudomonas aeruginosa lytic phage φDCL-PA6 and its variant φDCL-PA6α. Additionally, we characterized and evaluated the production of virulence factors and the ...

As the global burden of disease caused by multidrug resistant bacteria is a major source of concern, credible clinical alternatives to antibiotic therapy, such as personalized phage therapy, are ...

For biosafety reasons, we rescued reassortant virus using polymerase (PB2, PB1, PA) and nucleoprotein (NP) genes from the avian influenza strain and the remaining viral genes (HA, NA, M, NS) from the ...