A pre-B acute lymphoblastic leukemia cell line model reveals the mechanism of thalidomide therapy-related B-cell leukemogenesis. Journal: Journal of Biological Chemistry ...

A new role of STAT5B in B cell differentiation and B-ALL. Left: Physiological STAT5B level. The pre-BCR signaling cascade induces NF-κB binding.NF-κB upregulates IKAROS, which recruits the ...

New findings show that the stage of normal cell development at which B cells transform into leukemic cells impacts treatment ...

New findings show that the stage of normal cell development at which B cells transform into leukemic cells impacts treatment ...

A new study shows that the stage of normal cell development at which B cells transform into leukemic cells impacts treatment ...

Gene expression analyses have shown that CD179a is expressed in a sub-set of 10 to 15% of B-ALL cases. Because immunotherapies targeted to restricted stages of B-cell development may overcome the ...

Scientists at St. Jude Children’s Research Hospital and University Health Network showed that the stage of B-cell development ...

It affects the B cell lymphocytes. Around 75 out of every 100 people with ALL (around 75%) are this type. B cell ALL can be further divided into subgroups, the most common subgroup is precursor B cell ...

Blinatumomab Plus Chemotherapy New Standard for Children With B-Cell ALL — 3-year disease-free survival rate was 96% with blinatumomab versus 87.9% with chemo alone.

Kopmar NE, Quach K, Gooley TA, et al. Dose-adjusted EPOCH plus inotuzumab ozogamicin in adults with relapsed or refractory B-cell ALL: a phase 1 dose-escalation trial. JAMA Oncol. Published online ...

The CAR-T cell therapy Aucatzyl was approved for relapsed or refractory B-cell precursor acute lymphoblastic leukemia based on findings from the FELIX trial. The Food and Drug Administration (FDA) ...