Evolution of a hyper-mutable locus delivers foresight Through the analysis of more than 500 mutations, the study uncovered ...

A new study by researchers at the Max Planck Institute for Evolutionary Biology (MPI-EB) sheds fresh light on one of the most ...

Phenotypic variation in mammals is frequently attributed to the action of quantitative trait loci (QTL) or the environment, but may also be epigenetic in origin. Here we consider a mechanism for ...

[15] Genotypic assays also have the potential to identify emerging mutations before the onset of phenotypic drug resistance. This has been best studied through serial line probe assay (LiPA ...

Scientists used to infer mutations from phenotypic changes, such as the development of drug resistance. Now, thanks to increasingly cost-effective and rapid DNA sequencing, more-sophisticated ways of ...

If you get a mutation in coding DNA, then the sequence of DNA could be changed. Changing the sequence of DNA can change the amino acids that make up the protein. This could have huge consequences.

Home > Pressemitteilung: Insights into Evolutionary Dynamics: ...

Phenotypic assays evaluate growth of clinical ... The methodology is designed to account for the net effect of resistance-associated mutations and their interactions with each other.

Researchers employed a programmable DNA base editing technology to introduce a knockout mutation in the ND5 mitochondria gene, aiming to investigate the resulting genotypic and phenotypic changes.