In this review, we discussed the mechanism of Notch signaling in lung, liver and colorectal cancer and explored future strategies and directions for cancer treatment by modifying the Notch signaling ...

Kuick Research Report Highlights Ongoing Developments In Molecular Switches Application Therapeutic Targets & Drug Delivery ...

Figure 7. The Notch signaling pathway in chondrocytes. When Notch signaling is produced, Notch ligand of adjacent cells bind to Notch receptor, then the receptor is cleaved by γ-secretase to release ...

we chose to investigate the potential role of endosomal chemokine receptor signaling on mechanisms governing this function. Applying a combination of pharmacological and cell biological approaches, we ...

Centre for Endocrinology, William Harvey Research Institute, Bart’s and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, U.K. School ...

Insulin binding induces structural changes within the receptor. These changes trigger a biochemical chain of events inside the cell, (signal transduction) that finally leads to the activation of the ...

We strive to develop medications that do only 1 or 2 things (ie, blocking serotonin reuptake or blocking D2 and 5HT2a receptors) and do nothing else. We assume that all other mechanisms of action ...

IGF1, IGF2 and insulin act primarily through tyrosine-kinase-linked receptors—the IGF1 receptor ... growth through both direct and indirect mechanisms of action. 4 In the past 2 decades ...

Large trolleys and suitcases are essential for long trips, but the right choice depends on practicality, comfort and means of transport. Here's how to find the perfect one.

Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain ...