Background Best current estimates of neuropathic pain (NeuP) prevalence come from studies using various screening detecting pain with probable neuropathic features; the proportion experiencing ...

This Review discusses how pain in osteoarthritis might involve adaptations of brain circuits, and suggests that osteoarthritis pain management should consider targeting central mechanisms of pain ...

Vertex Pharma's non-opioid painkiller suzetrigine was unable to perform better than placebo in a phase 2 trial in lumbosacral radiculopathy (LSR), a form of neuropathic back pain, ahead of an FDA ...

Pain signals originating in the body’s periphery are conveyed to the brain along a relay of neurons in four different parts of the ascending sensory pathway: the dorsal root ganglion, dorsal ...

Diabetic neuropathic pain (DNP) is one of the most prevalent complications of diabetes ... leading to inhibition of glutamate transporter function and amplification of nociceptive signaling.

Information on the advantages and challenges encountered by this process could help inform the development of future guidelines for neuropathic pain. The 2015 guidelines, 3 the first iteration to use ...

Capitalizing on the flexibility of tiny cells inside the body's smallest blood vessels may be a powerful spinal cord repair ...

Stanford researchers have recreated a key human pain-sensing nerve circuit in a lab dish, using fused mini-organoids that mimic the ascending sensory pathway from skin to brain. This breakthrough ...

Scientists have re-created a pain pathway in the brain by growing four key clusters of human nerve cells in a dish. This laboratory model could be used to help explain certain pain syndromes, and ...