这篇综述深入探讨了核因子κB（NF-κB）在免疫反应、慢性炎症和肿瘤发生中的双重角色。文章系统梳理了NF-κB通过经典（canonical）和非经典（noncanonical）通路调控炎症因子（如TNF-α、IL-6）和抗凋亡蛋白（如Bcl-2、XIAP）的分子机制，并强调其在类风湿关节炎（RA）、炎症性肠病（IBD）和多种癌症中的 ...

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