Local anesthetics such as lidocaine block pain effectively, but they also impair motor and autonomic functions by indiscriminately blocking sodium channels in all neurons. Binshtok et al.

Spine injections should not be given to adults with chronic back pain because they provide little or no pain relief vs. sham ...

Pregnancy (Cat.B). Nursing mothers. Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials ...