Magnetically labeled biomolecule detection technology is playing an increasingly important role in disease diagnosis, drug development and other fields. Biomolecules labeled with magnetic particles ...

Single-molecule Förster resonance energy transfer (smFRET) is a powerful method for studying the conformational dynamics of a biomolecule in real-time. However, studying how interacting ligands ...

tRNA therapy could potentially help to counteract the effects of these mutations. The focus of current research is designing “suppressor” tRNAs that can bypass these premature stop signals and ...

The work is a valuable contribution to understanding the mechanism of nuclear export of tRNA in budding yeast. The authors present solid evidence that Dbp5 functions in parallel with Los1 and Msn5 in ...

Quantum-Si has been granted a patent for compositions that can detect single molecules in a sample. The patent describes a labeled molecule consisting of a reactant connected to two or more ...

The α-amino group of valyl-tRNA has been combined chemically with a nitroxide spin label through an amide linkage. This spin-labeled aminoacyl-tRNA has an electron paramagnetic resonance spectrum ...

Abstract The α-amino group of valyl-tRNA has been combined chemically with a nitroxide spin label through an amide linkage. This spin-labeled aminoacyl-tRNA has an electron paramagnetic resonance ...

Researchers from Helmholtz-Zentrum Dresden-Rossendorf presented the discovery of novel small molecule-based radiotracers for PD-L1 PET or SPECT imaging.

Juette and coworkers employed single-molecule fluorescence, cryogenic-electron microscopy structures, and in vivo measurements to investigate the mechanism whereby two natural products with potential ...

Researchers developed a radio-labeled molecule that allows real-time PET imaging of inflammation and activation of innate immune activity. This would allow physicians to pinpoint areas of ...

The molecule may be able to pinpoint areas of inflammation in a variety of clinical settings, such as inflammatory diseases, infections and immunotherapy -related side effects.