Itaconate is a crucial anti-infective and anti-inflammatory immunometabolite that ... The NRF2 protein level and activity are regulated by ubiquitination and degradation by E3 ligase complexes ...

Objective: Through network pharmacology and molecular docking technology, the hub genes, biological functions, and signaling pathways of 4-Octyl itaconate (4-OI) against sepsis were revealed. Methods: ...