Homologous recombination (HR) is a ubiquitous genetic phenomenon, essential when environmental and internal stressors cause DNA damage, which can lead to breakages in both strands of double-stranded ...

Homologous recombination DNA repair deficiency (HRD) is associated with sensitivity to platinum and poly (ADP-ribose) polymerase inhibitors in certain cancer types, including breast, ovarian, ...

Deep Learning Artificial Intelligence Predicts Homologous Recombination Deficiency and Platinum Response From Histologic Slides – An ASCO Reading Room selection September 18, 2024 • 2 min read ...

Homologous recombination deficiency (HRD) is a well-described phenotype of some prostate cancers; however, current biomarkers for HRD are imperfect and rely on detection of single gene alterations in ...

We already showed that AsiDNA disrupts the homologous recombination repair in different HRP tumor models, and therefore, induces a functional HRD that sensitizes HRP tumors to PARP inhibitors.

Be able to describe homologous recombination deficiency in the scheme of DNA damage and its role in cancer therapy, focusing on high grade ovarian epithelial cancers Summarize the method of software ...

Two competing models exist for homologous recombination. The results of this study support a model where the double-stranded DNA is not unwound during the homology search. (Shibata et al. Nucleic ...

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Next-generation PARP inhibitor demonstrates clinical benefit in patients with homologous recombination repair-deficient breast cancer Drug has higher selectivity for PARP1, improving safety and ...

Study: The coronavirus recombination pathway. Image Credit: eyeidea/Shutterstock.com Background Recombination is believed to aid in the transmission of coronaviruses between different species ...