It is the story of Chernobyl’s feral dogs, and it begins not with a whimper but with a nuclear boom a boom that, some four ...

PURPOSEThe ability of the Geneva homologous recombination deficiency (HRD) test to predict progression-free survival (PFS) in patients with high-grade ovarian cancer treated with poly (ADP-ribose) ...

The Association for Molecular Pathology announced the publication of best practice recommendations for clinical laboratories developing and performing homologous recombination deficiency (HRD ...

PURPOSECancers with homologous recombination deficiency (HRD) can benefit from platinum salts and poly(ADP-ribose) polymerase inhibitors. Standard diagnostic tests for detecting HRD require molecular ...

Homologous recombination is a fundamental mechanism driving the evolution of bacteria. Recombination rates have been found to vary tremendously across species but quantifying the rates of ...

About 50% of High Grade Serous Ovarian Cancer exhibit a high degree of genomic instability due to mutation of genes involved in Homologous Recombination (HRD) and such defect accounts for synthetic ...

Researchers unravel key steps in the process of homologous recombination DNA repair, providing potential new avenues for cancer research.

The Homologous Recombination Scores of Several Feature Samples Varied Significantly The signatures of HR-related modules were scored using PCA. The results indicated that the HR scores of the Lund2, ...

The work here shows that they collaboratively promote reciprocal recombination between two homologous sequences. Remarkably, they are very frequently subjected to reciprocal recombination, even though ...