Stress‐inducible phosphoprotein 1 (STI1; STIP1; HOP) is a co‐chaperone that simultaneously interacts with Hsp70 and Hsp90, but whose function in vivo remains poorly understood. We combined in‐depth ...

The R2TP complex, a specialised co‐chaperone assembly comprising the AAA+ ATPases RUVBL1 and RUVBL2 along with RPAP3 and PIH1D1, is pivotal in orchestrating the assembly and stabilisation of a ...

MBT-C101 is a selective, potentially first-in-class potent HSP90 chaperone-mediated degrader of PI3Kα, for the treatment of breast cancer. It was developed by Magicbullet Therapeutics Inc. using the ...