Leptin is produced in adipose tissue and suppresses appetite in the brain. If the leptin receptor in this cluster of PNOC nerve cells was removed, the mice ate more and became overweight. "It was ...

This study showed that the glucocorticoid receptor can only use regulatory regions that are already active in prostate cancer cells." Laura Helminen, Doctoral Researcher, University of Eastern Finland ...

When both the androgen and the glucocorticoid receptor were activated simultaneously, the number of binding sites for the glucocorticoid receptor in prostate cancer cells doubled.

Furthermore, loss of brain vascular nuclei across various cell types, including endothelial cells, smooth muscle cells, and pericytes, was previously observed, with the matrix pericytes being ...

Would this Trojan horse work in vivo? The scientists loaded BI-hTFR1 viruses with luciferase genes, then added them to primary and cultured human brain endothelial cells. These cells shunt transferrin ...

Bacteria can slip into the brain by commandeering cells in the brain’s protective layers, a new study finds. The results hint at how a deadly infection called bacterial meningitis takes hold.

The endocannabinoid system (ECS) is a key regulator of stress responses, and CB1—encoded by the Cnr1 gene—is the main ECS receptor in the brain, the team continued, noting “… ...

The tweaked receptor preferred larger odor molecules, which confirmed that the size and chemistry of the binding pocket tunes the receptor to detect only a narrow set of molecules. The structural ...