Nitazenes primarily act on gamma-aminobutyric acid (GABA) receptors in the brain, leading to enhanced inhibitory neurotransmission and producing sedative, hypnotic, and anxiolytic effects.

What are nitazenes? Nitazenes are a class of designer drugs that emerged in the 2010s. They are derivatives of benzodiazepines, which are a class of psychoactive drugs used primarily for treating ...

Before 1846, surgery was a crude and brutal undertaking, typically performed on conscious patients lashed to their beds. Then ...

Neurosteroids, which modulate GABA A and NMDA receptors and regulate the hypothalamic–pituitary–adrenal axis, show promise as alternative treatments for treatment-resistant depression.

Cage-type calix[4]pyrroles 2 and 3 bearing two additional pyrrole groups on the strap have been synthesized. Compared with the parent calix[4]pyrrole (1), they were found to exhibit remarkably ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Alcohol has sedative and anxiolytic effects similar to those produced by drugs (e.g., barbiturates and benzodiazepines) that act on GABA A receptors. In general, studies that have investigated ...

If you believe the hype, CBD oil can fix just about anything. It stimulates the same response as social contact, chocolate and exercise. But what does the science say and is it even legal?

1. 东南大学生命科学与技术学院的科学家在Cell Reports期刊上发表了一篇关于微小RNA miR-7调控埃及伊蚊雌蚊繁殖能力的研究论文。

Receptor pharmacology is the study of the interactions of receptors with drugs/pharmaceuticals and other xenobiotics. A basic tenet of receptor pharmacology is that a drug’s effect is directly ...

A former member of police staff has been jailed for passing confidential information to her drug dealer boyfriend. An investigation by South Wales Police found Lucy Langmead, 44, from Pontypridd ...

In addition, the team aims to develop drugs that activate these receptors, which may provide a novel way to lower blood pressure and prevent heart disease. Read the full paper in Cardiovascular ...