Recent work has shown us that G3BP nucleation of stress granules in the absence of virus infection activates PKR, resulting in phosphorylation of eIF2alpha and activation of NF-kB and JNK signal ...

Cytoplasmic RNA granules ((Stress Granules (SG) and P-bodies) function in translation regulation by sequestering translationally-silenced mRNAs but also play prominent roles in the integrated stress ...