In a preprint posted on bioRxiv, Profluent introduces a new method which now incorporates structural and functional context to protein language models for conditioned design. The approach, termed ...

Solving the structure of an amyloid protein gives new insight into limb-girdle muscular dystrophy type 3 (LGMD D3) and functional protein aggregation. LGMD D3 is a rare disease characterized by slow ...

The structure of protein sets the foundation for its interaction with other molecules in the body and, therefore, determines its function. This article will cover the structural principles of ...

Traditionally, high-protein food and drink makers have leant heavily on whey, a byproduct of the cheese and yogurt-making process. But as consumer demand evolves, innovators are exploring new ...

Every company needs an organizational structure—whether they realize it or not. The organizational structure is how the company delegates roles, responsibilities, job functions, accountability ...

De novo protein design. In 2024, David Baker won the Nobel Prize in Chemistry for computational protein design and the prize was shared with Demis Hassabis, and John Jumper for protein structure ...

I n the rapidly advancing field of computational biology, a newly peer-reviewed review explores the transformative role of deep learning techniques in revolutionizing protein structure prediction ...

Scientists have for the first time looked deep into the protein structure that may determine our vision - and discovered that it is much more dynamic than previously thought.

Cellular structure without a membrane ... Further demarcation of the functional specificity of LLPS ... liquid condensates—or ...

image: (a) Protein sequence-structure co-design with PocketGen; (b) Dual-layer graph Transformer encoder; (c) Pre-trained protein language model for sequence prediction and efficient fine-tuning.

In 2003, Baker and his team generated the first de novo protein, a 93-amino acid protein called Top7. 1 According to Baker, the fact that the X-ray structure of Top7 aligned well with their ...