Mar. 13, 2025 — A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States ...

Back in 2014, a woman with advanced cancer pushed Adrienne Boire’s scientific life in a whole new direction. The cancer, ...

This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

《Cell Death & Differentiation》：ATOH8 confers the vulnerability of tumor cells to ferroptosis by repressing SCD expression ...

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China ...

Macrophages, crucial for immune response, are affected by ferroptosis. Erastin and RSL3, ferroptosis inducers, reduce pro-inflammatory cytokines in macrophages. In tumor microenvironments, substances ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression.

Erastin and RSL3, ferroptosis inducers, reduce pro-inflammatory cytokines in macrophages. In tumor microenvironments, substances like 8-OHG drive macrophage polarization towards the ...