Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression.

State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, ...

In contrast, the transcription levels of ferroptosis regulatory factors—such as solute carrier family 7member 11 (SLC7A11), ferritin light chain (FTL), ferritin heavy chain 1 (FTH1), NAD(P)H quinone ...

Inhibition of EV biogenesis with GW4869 prevented FtH release and restored LIP accumulation, lipid peroxidation, and ferroptosis sensitivity in COV318 and PEO4 cells. Discussion: Overall, our results ...