Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression.

State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, ...

推荐阅读：本文聚焦 HNSCC 中 ferroptosis，阐述其分子机制与治疗策略，极具科研价值。 头颈部鳞状细胞癌（HNSCC）中 ferroptosis 的分子机制及治疗研究进展 一、ferroptosis 概述 ferroptosis 是一种受调控的、依赖铁的细胞死亡方式，脂质过氧化和线粒体功能障碍在其中 ...

Inhibition of EV biogenesis with GW4869 prevented FtH release and restored LIP accumulation, lipid peroxidation, and ferroptosis sensitivity in COV318 and PEO4 cells. Discussion: Overall, our results ...

Using KEGG pathway analysis, DEPs were significantly enriched in endocytosis pathways, terpenoid backbone biosynthesis pathways, and the ferroptosis pathway (Figure 2C). These 50 DEPs in senescent ...

In addition to excessive lipid peroxidation, iron overload is one of the features of ferroptosis. Ferritin heavy chain 1(FTH1) and Transferrin receptor protein 1 (TfR1) delicately regulate the storage ...

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Furthermore, we identified a loss of RPMs during aging, underlain by the combination of proteotoxic stress and iron-dependent cell death resembling ferroptosis. These impairments lead to the retention ...