"Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat." Nature, 2012, DOI: 10.1038/nature11508. About RIKEN.

Non-coding antisense RNA can be used to stimulate protein production Date: October 16, 2012 Source: RIKEN Summary: While studying Parkinson's disease, an international research group made a ...

image: This shows the sense of antisense RNA. view more Credit: SISSA. To synthetize proteins, the DNA needs RNA molecules serving as short "transcriptions" of the genetic information.

Antisense instead binds to the RNA messenger molecules that ferry genetic information from the DNA to the cell. By binding to RNA, antisense prevents proteins involved in disease from ever being ...

Bidirectional transcription from the promoter region and enhancers produces non-coding promoter RNA (pRNA) and enhancer RNA (eRNA), respectively. Natural antisense transcripts (NATs) originating from ...

For at least 30 years scientists and drug developers bent on a sorely needed new class of therapeutics have been studying antisense RNA. The concept is deceptively simple: Binding of an ...

Much of the non-coding RNA is produced as the complementary strand to mRNA and is therefore referred to as antisense RNA (asRNA). Their function has been unclear for a long time.

They also confirmed several sets of known gene-enhancer pairs and generated a list of 50,000 possible pairs. The team is now testing their approach using other types of cells.

"Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat." Nature, 2012, DOI: 10.1038/nature11508. Journal information: Nature.