OPC-4392 was shown to be effective against negative symptoms and showed no propensity to induce extrapyramidal symptoms in individuals with schizophrenia ... isoforms of the dopamine receptors ...

Generally, the pathophysiology of schizophrenia is believed to be determined by imbalances in neurotransmitters, in particular dopamine and serotonin, and in four neural pathways in the brain ...

Feb. 19, 2025 — A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct ...

The symptoms of schizophrenia ... One such chemical is called Dopamine which is found to be increased in schizophrenia patients. These chemicals are involved in certain pathways or circuits ...

Historically, most antipsychotic drugs for schizophrenia have targeted dopamine pathways, specifically the D2 receptors, to manage symptoms. However, this approach has limitations, as many ...