Generally, the pathophysiology of schizophrenia is believed to be determined by imbalances in neurotransmitters, in particular dopamine and serotonin, and in four neural pathways in the brain ...

Feb. 19, 2025 — A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct ...

Historically, most antipsychotic drugs for schizophrenia have targeted dopamine pathways, specifically the D2 receptors, to manage symptoms. However, this approach has limitations, as many ...

Investigational drug SPN-820, which activates the mTORC1 pathway, failed to significantly reduce depressive symptoms compared ...