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DNA-binding C2H2 zinc finger proteins also regulate RNA processing, researchers discover
C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic information from DNA to messenger RNA (mRNA). As there are more than 700 ...
The Scientist3d
Unstable Protein Variants Linked to Many Human Diseases
The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving ...
Scientists create protein ‘seeds’ that trigger key pathological features of ALS and frontotemporal dementia
Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, researchers report ‘seeding’ this accumulation through fragments of the culprit ...
Nature1y
Do Transcription Factors Actually Bind DNA? DNA Footprinting and Gel Shift Assays
Kadonaga, J. T., & Tjian, R. Affinity purification of sequence-specific DNA binding proteins. Proceedings of the National Academy of Sciences 83, 5889–5893 (1986) ...
ChIP-mini technology advances analysis of DNA-protein interactions in pathogenic bacteria
and quantitatively analyzing changes in DNA binding positions and intensities of two crucial proteins, H-NS and RpoD.