When normal DNA repair systems are broken, as in BRCA-deficient cancers, cells rely on backup proteins like RAD52 to keep growing. If RAD52 is blocked, the cancer cells can’t fix their DNA and die.

Rosalind Franklin, James Watson and Francis Crick discovered the structure of DNA—that molecular blueprint for life—over 70 years ago. Today, scientists are still uncovering new ways to read it.

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

Revolutionizing cell biology: first-ever artificial cell nuclei created in living egg from purified DNA injection Groundbreaking study uncovers key mechanisms behind functional nucleus formation ...

The UCL School of Pharmacy has a long history of characterisation of alternative DNA structures, from the first crystal structure of a different DNA structure called a G-quadruplex, in a 2011 ...

Crystallized alternative DNA structure sheds light on insulin and diabetes Date: September 6, 2024 Source: University College London Summary: The first crystal structure of an alternative DNA ...

The knot-like i-motif structure protruding from DNA’s double helix has been mapped in 50,000 locations in the human genome, concentrated in key functional areas including regions that control gene ...

Summary: Researchers identified a novel mechanism that impacts memory formation through changes in DNA structure, specifically G-quadruplex DNA (G4-DNA). Their study reveals that G4-DNA accumulates in ...

Inside the new Seattle Hub for Synthetic Biology, which uses DNA to ‘record biology over time’ by Charlotte Schubert on April 2, 2024 at 10:24 am Share 28 Tweet Share Reddit Email ...

RNA is involved in a vast number of biological processes that are central to life, and its structure is quite diverse in terms of nucleobase structure (over 120 modified nucleobases), molecule size ...