Epigenetic inhibitors as a promising new antimalarial intervention strategy? A new study identifies an inhibitor of gene regulation that specifically kills the malaria pathogen.

Thanks to the growing field of epigenetics, we're learning more about the interplay of genetic inheritance and environment in ...

Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to ...

A clinical trial found that omega-3 supplementation modestly slowed biological aging, with additional benefits when combined with vitamin D and exercise.

including DNA methylation, and that DOT1L associates with ERα in BC cell chromatin as a component of a multiprotein regulatory complex, we investigated the functional impact of ERα and DOT1L ...

Isolated RNA was transcribed into complementary DNA using iScript (Bio ... such as histone methylation and acetylation, are involved. To investigate the role of epigenetic histone modifications on ...

Treatment with the DNA methylation inhibitor decitabine lowered the methylation age of organoids from 22 months to 10 months, showing the potential of organoids to model extrinsic effects on ...

It essentially hacks the immune cells, transferring its own faulty mitochondrial DNA (mtDNA ... and responses to immune checkpoint inhibitors were evaluated. Melanoma and lung sample analysis ...

Notably, inhibiting HMOX1 with the specific inhibitor Znpp significantly reduced osteocyte death and preserved bone integrity, whereas the classical ferroptosis inhibitor, Fer-1, had a lesser effect.

By comparing genetic mutations to epigenetic modifications, they found that mutations were predictably correlated with changes in DNA methylation, one type of epigenetic modification. They found ...

aDepartment of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, Robert Koch Street 40, Göttingen, Germany bDivision of Matrix Biology, Department of Medicine, ...