The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system.

Dysregulation of mitochondrial reactive oxygen species (mtROS) contributes to intestinal tumorigenesis. Here the authors report that excessive mtROS induces the release of mitochondrial PGAM5 into ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Viagra (sildenafil) is an oral drug used to treat erectile dysfunction (ED) that starts working within one hour and can last for around four hours. It was the first drug approved for the use of ED, a ...

Biochemical and physiological mechanisms of adaptation of organisms to the marine environment. Special emphasis is on biological responses to temperature, salinity, carbon dioxide, pH and bicarbonate ...

The research is published in the Journal of Applied Physiology. This is the first time people with type 2 diabetes (T2D) have been given a drink with ketone esters—a supplement that is meant to ...

While factors such as myocardial ischaemia, worsening renal function, volume overload and chronic pulmonary disease may contribute to decompensation, the primary pathophysiology in hypertensive AHF ...

Adenomatous polyps typically do not cause symptoms unless they progress to colon cancer. Even then, there may be no sign of a problem until the malignancy is advanced. This is why colon cancer ...

The evolution of a disease resulting in functional changes in your body is known as pathophysiology. To understand COPD’s pathophysiology, it’s important to understand the structure of the ...

Nancy Leftenant-Colon, who battled racial discrimination in a barrier-breaking career as a military nurse, serving as the first African American in the regular Army Nurse Corps and later caring ...

Colon cancer cases are soaring in young people, alarming experts and leaving doctors scrambling for answers as to why. Now, a study published by a team of international researchers in the journal ...