With mostly solid data, the authors observe that restoring expression of vATPase subunits and treatment with Astaxanthin ameliorate mitochondrial function in a model of renal epithelial cells, opening ...

Feb. 20, 2025 — Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA ...

Kidney organoids express renal drug transporters, OAT1, OAT3, and OCT2, while a human proximal tubular cell line shows the absence of OAT1 and OAT3. Tenofovir and aristolochic acid (AA) induce ...

Clinical and animal model validation confirmed heightened CAV1 expression in CAD. In vitro experiments demonstrated that CAV1 can directly promote chronic renal allograft interstitial fibrosis by ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

Results—Mucosal injury was induced by both ischaemia and ischaemia/reperfusion. Detachment of epithelial cells from the villous stroma was an early morphological change indicating mucosal injury. More ...

complex cells that invade your body. Bacteria can survive inside or outside your body without the need for a host. Bacterial infections occur when there are too many harmful bacteria for your immune ...

Background: We showed that intestinal epithelial stem cells (IESCs) obtained from healthy young donor rats and transplanted to aging animals after stroke reduced infarct volume and sensorimotor ...

snu.ac.kr Background Epithelial to mesenchymal transition (EMT) is associated with the pathophysiology of chronic rhinosinusitis with nasal polyp (CRSwNP). Wnt signaling is causative for EMT, whereas ...

Correspondence to: Dr G J Gores Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA; gores.gregorymayo.edu ...