Generative Phosphoproteomics AP3 platform designed to enable streamlined, rational drug discovery, with proprietary, proteome-wide SAR delivering ...

Event to be held via webcast on March 25, 2025 at 4:00 p.m. ET To highlight differentiated drug discovery capabilities with ...

Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...

为解决头颈部鳞癌（HNSCC）放疗效果不佳问题，英国研究人员开展 Chk1 和 Wee1 激酶抑制剂联合放疗研究，发现可增强 HNSCC 对 X 射线和质子束疗法（PBT）的敏感性，为治疗提供新方向。 头颈部鳞癌（Head and Neck Squamous Cell Carcinoma，HNSCC）是一种常见的恶性肿瘤 ...

Mechanistically, the compound induced cell cycle arrest: in SW-480 and Caco-2 cells, it halted progression at the S phase through the ATR/Chk1 pathway, while in HCT-116 cells, it caused arrest at ...

Mechanistically, the compound induced cell cycle arrest: in SW-480 and Caco-2 cells, it halted progression at the S phase through the ATR/Chk1 pathway, while in HCT-116 cells, it caused arrest at ...

Also referred to as prexasertib, Acrivon’s lead candidate ACR-368 is a selective small molecule inhibitor that targets checkpoint kinase 1(CHK1 ... are crucial for pathway-based drug design ...

1Department of Radiation Oncology, Inselspital Bern University Hospital, Bern, Switzerland. 2Department for BioMedical Research, Radiation Oncology, University of Bern, Bern, Switzerland. 3Graduate ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

Figure 1 Mechanisms of radioresistance caused by DNA damage repair in NSCLC. Radiation induced DNA damage response can activate the DNA repair pathway, of which SSBs can be repaired through ATR/Chk1 ...