Nuclear receptors regulate transcription in response to ligand signals and enable the pharmacological control of gene expression. However, many nuclear receptors are still poorly explored and are not ...

Here, the authors report a chemogenomics library of NR3 ligands to reveal elusive effects of NR3 receptor modulation in phenotypic settings, revealing potential NR3-mediated effects in endoplasmic ...

In industrial settings and processes, yeasts may face multiple adverse environmental conditions. These include exposure to non-optimal temperatures or pH, osmotic stress, and deleterious ...

This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing ...

P2Rank: Protein-ligand binding site prediction from protein structure based on machine learning.