Scientists are exploring gene editing as a way to correct trisomy at the cellular level. Using CRISPR-Cas9, researchers successfully removed extra copies of chromosome 21 in Down syndrome cell lines, ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

In December 2023, through the development efforts of CRISPR Therapeutics and Vertex Pharmaceuticals, their decades-long ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

CRISPR-Cas9 is a precision genome editing technology that can knock out, activate or fine-tune the expression of individual genes. We provide access to CRISPR KO (knockout), CRISPRi (interference ...

Widely used as a genome editing tool, the CRISPR-Cas9 system allows researchers to precisely induce frameshift mutations in specific genes or insert foreign nucleic acid sequences into a cell’s DNA.

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...

By using clustered regulatory interspaced palindromic repeats (CRISPR)-CRISPR-associated protein (Cas9) knock-out screens, they systematically deleted each gene to see if its absence allowed tumors to ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in ...

Both gene knockout and knock-in models are powerful ... regularly interspaced short palindromic repeats (CRISPR)/associated ...

CRISPR/Cas9, a groundbreaking gene-editing technology, holds the potential to transform oilseed production in Kashmir ...

When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...