Women with breast cancer who were also carriers of the BRCA1 or BRCA2 mutation and received textured breast implants as part of their reconstructive surgery after mastectomy were 16 times more ...

Potential bioinformatic confounders are only weakly related to a small set of mutation spectrum features. We find that clock-like mutational signatures previously inferred from human cancers cannot ...

This novel understanding of BRCA2's role in PARP inhibition could significantly influence the development of more effective anti-cancer drugs. The researchers found that intact BRCA2 protects RAD51, ...

Scientists upends scientific understanding of how anticancer drugs kill cancer Date: March 6, 2025 Source: UMass Chan Medical School Summary: BRCA1 and BRCA2 genes play a crucial role in repairing ...

Scientists have characterized the role of thousands of mutations in the BRCA2 cancer gene, findings that may help reassure worried patients about their cancer risk or guide doctors toward better ...

Six-year results continued to show the clinically meaningful efficacy of adjuvant olaparib vs placebo in patients with BRCA1/2 mutation–positive, HER2 - negative high-risk breast cancer, according to ...

People of Ashkenazi Jewish descent are at higher risk of developing pancreatic cancer because they are more likely than other groups to have a BRCA1 or BRCA2 mutation. These mutations increases a ...

Prostate cancer: Men with both BRCA1 and BRCA2 mutations are 4.5 to 8.3 times more likely to develop prostate cancer. Those with BRCA2 mutations (unlike BRCA1) often develop aggressive prostate cancer ...

The tests the oncologist ran showed Dedmon was positive for the BRCA2 gene mutation. “That was the beginning of my risk management, knowing that I am a carrier,” explains Dedmon.

If you have a BRCA2 mutation, most studies show you may have around a 20% to 40% chance of developing prostate cancer over your lifetime. For some people, research shows the odds may be as high as ...