Indeed, mutations in BRCA1 are known to predispose individuals to hereditary breast and ovarian cancers. So, as BRCA-deficient cells had previously been shown to be highly sensitive to the effects ...

More and more studies show that men face risks of cancer from BRCA1 and BRCA2 genetic mutations that are most often associated with breast and ovarian cancers in women. According to a JAMA ...

Pharmacogenomics. 2012;13(13):1523-1535. 5-year survival for stage III and IV (%): carriers, 38.1; noncarriers, 24.5 Median survival: p = 0.002 5-year survival for stage III and IV: p < 0.001 [46 ...

The former NBC news anchor, 49, revealed last month in an Instagram post that she had tested positive for the BRCA1 gene mutation, putting her at a higher risk for breast and ovarian cancer.

A new study on circulating tumor DNA (ctDNA) testing for advanced breast cancer has unveiled encouraging results, with high ...

Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...

AI chipmaker Nvidia and research partners have created what they call the largest artificial intelligence system yet for ...

Dr. Chandler Park discusses the importance of genetic testing and personalized care in patients with genitourinary cancers.

Most studies assessing BPO are retrospective studies and nonrandomized ( Table 1) and have been evaluated in women at risk for carrying BRCA1/2 mutations. A study by Lu et al [42] reviewed the ...