SS18-SSX2 in a human synovial sarcoma cell line also directly suppresses expression of MCL1 and BCL2A1 and can be identified at their promoters. (a) SYBR green qPCR of cDNAs made from total RNA ...

Bispecific antibody GEN-1057 induces apoptosis through DR4 and FAPα dual engagement . May 2, 2025. No Comments. The use of mimicking antibodies that activate death receptors (DRs) to selectively ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Leveragen’s Singularity Sapiens Mouse platform represents the latest technology to circumvent these challenges, producing fully human single-domain antibodies with enhanced diversity and superb ...

Before humanization, mouse antibody K D =6.38E-12M. Image Credit: Sino Biological. After humanization, humanized antibody K D =3.90E-12M. Image Credit: Sino Biological . Nanobody humanization.

The collaboration brings together DPBIO’s Cytospark™ droplet microfluidic single-B cell antibody discovery platform and Leveragen’s Singularity Sapiens Mouse, a next-generation genetic model ...

Gilead Sciences has expanded its antibody discovery collaboration with AbCellera. The expanded agreement will see AbCellera apply its technologies to up to eight new targets across multiple ...

Researchers at Baylor College of Medicine and Rice University have received a $2.3 million Breakthrough Award from the Department of Defense Congressionally Directed Medical Research Programs to ...