vanderbilt.edu Design Tff1-knockout (Tff1-KO) mice, immunohistochemistry, luciferase reporter, qRT-PCR, immunoblot, and phosphatase assays were used to examine the role of TFF1 on β-catenin signalling ...

Instead, we provide here proof-of-concept that a locked nucleic acid (LNA)-based inhibitor of miR-34a may be useful for treatment exclusively in HCCs with β-catenin mutation. For primary culture of ...

Methods Inflammatory markers and EMT-related molecules were evaluated in NP models using adenomatosis polyposis coli (Apc) Min/+ mice with activated Wnt signaling and NP models treated with Wnt ...

“In 19 of the top economies of the world, they have embraced nuclear because it’s a zero emissions technology and they don’t have a credible pathway to net zero without it,” Mr Dutton said.

As advisors talk with their clients about reallocating assets, there may be opportunity for a discussion about more novel strategies that avoid any beta exposure to the S&P 500. AGF Capital Partners ...

Two years later, a close interaction between APC and β-catenin was demonstrated (8, 9), and as APC mutations were found at high frequencies in colorectal adenomas and carcinomas, it was soon realized ...

In the present study using cell lines, animal model and database analysis, we show that FMOD is crucial for breast cancer cell migration and invasion (BCCMI) via activation of ERK; expression of FMOD ...

Wnt/β-catenin signaling is essential for BBB development and maintenance in endothelial cells (ECs) in most CNS vessels. Here we show that in mouse development, as well as in adult mouse and zebrafish ...

Genetic deletion of Hif-3α2 by CRISPR/Cas9 genome editing increases, while Hif-3α2 overexpression decreases, Wnt/β-catenin signaling. This action is independent of its HRE-dependent transcriptional ...