Antifungal agents are substances that inhibit the spread of fungi by killing fungal cells or spores or preventing their growth. Antifungal proteins (AFPs) produced by filamentous ascomycetes are ...
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Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States Department of Pharmacology, University of ...
Despite significant advancements in pharmaceutical sciences, conventional drug delivery system remains limited by issues like poor permeability, toxicity, suboptimal efficacy, and inadequate targeting ...
The discovery of a new preclinical compound with strong antifungal activity against multidrug-resistant pathogens is described in Nature.The drug, named mandimycin, is a member of a known family ...
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Mandimycin is part of the family of glycosylated polyene macrolides that has provided many antifungal drugs, including AmB, nystatin and natamycin. Fungal resistance to these drugs is rare ...
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