Figure 1 Overview of the ligand-receptor pairs between dNK cells and EVT cells. KIR2DL1, 2DL2 and 2DL3 are inhibitory receptors containing ITIMs, which bind with HLA-C on EVT cells. KIR2DS1 also ...

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In the inhibitory receptors, the phosphorylated tyrosine-based inhibitory motifs (ITIMs) act as docking sites for recruiting the SHP-1 protein tyrosine phosphatase, preventing cellular activation (8).