The tau protein, which, when it becomes toxic ... These drugs often cause side effects such as memory loss and limited motor function. Instead of targeting glutamate directly, the USC researchers ...

Phosphorylation enables tau protein to undergo reversible liquid–liquid phase separation (LLPS), forming micrometer-sized droplets, a property not seen in unmodified tau.

Using a novel quantitative chemoproteomic strategy, the team uncovered a protective role of dopamine (DA) in regulating the function of the microtubule-associated protein Tau. This discovery ...

people’s brain function is already declining. The scans are also expensive and not available at all hospitals. More sensitive ways to detect amyloid and tau, another protein related to the ...

Wegmann at German Center for Neurodegenerative Diseases (DZNE) in Berlin, Germany, and colleagues was titled, "Experimental evidence for the age dependence of tau protein spread in the brain." ...

“Interestingly, KIBRA restored synaptic function and memory in mice, despite not fixing the problem of toxic tau protein accumulation,” said Kristeen Pareja-Navarro, co-first author of the study. “Our ...

Abnormal accumulation of tau protein in the brain has been associated with neurodegeneration and cognitive decline in AD patients. BIIB080 is an investigational antisense oligonucleotide therapy ...

Scientists have discovered a new protein pathway involved in neurodegeneration by studying “mini-brain” organoids made from ...

As previously announced, results from the Phase 1b study showed dose-dependent reductions in soluble tau protein in cerebrospinal ... measures of cognition and function. The Phase 2 CELIA study ...