Over the past several centuries, the integration of contemporary medical techniques and innovative technologies, like genetic sequencing, have played a pivotal role in enhancing our comprehension of ...

Cerebrovascular events (CVEs) are a dreaded complication of transcatheter aortic valve replacement (TAVR). They are associated with significant mortality, morbidity, and reduced quality of life and ...

Methods and Results Cis‐expression quantitative trait loci data for druggable genes were used as instrumental variables. The primary outcome was the modified Rankin Scale score at 3 months after ...

The study included 250 patients (antithrombotic agent nonusers, 42.0%; oral anticoagulant users, 34.0%; and antiplatelet users, 24.0%). The primary outcomes did not differ among the 3 groups. Among ...

Asif KS, Otite FO, Desai SM, Herial N, Inoa V, Al-Mufti F, Jadhav AP, Dmytriw AA, Castonguay A, Khandelwal P, et al; Global Executive Committee of the MT-GLASS Study. Mechanical thrombectomy global ...

Familial hypercholesterolemia (FH) is the paradigm of the established relationship between increased low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease. 1,2 This monogenetic ...

Methods and Results— A total of 418 subjects with type 2 diabetes were randomly assigned to 200 mg micronized fenofibrate daily or placebo. The mean follow-up time was 39.6 months. LDL peak particle ...

Therapies that aim to achieve early arterial recanalization during interhospital transfer—before the EVT procedure—have the potential to substantially improve functional outcomes. Currently, ...

Methods and Results— We conducted a case-control study nested in the Cardiovascular Health Study. We identified 214 cases of fatal IHD (fatal myocardial infarction and coronary heart disease death) ...

Extensive evidence indicates that extracellular matrix (ECM)/integrin receptor signaling is also an important regulator of myocardial hypertrophy. Upregulation of collagen III, fibronectin, ...

imageIntracranial atherosclerosis‐related large‐vessel occlusion (ICAS‐LVO) stands as a predominant cause of acute ischemic stroke (AIS) worldwide, contributing significantly to morbidity and ...