Background and aims: Cyclooxygenase 2 (COX-2) is upregulated in most colorectal cancers and is responsible for metabolism of the endogenous cannabinoid, anandamide, into prostaglandin-ethanolamides ...

Objective To appraise the evidence that pathophysiological mechanisms and individualised treatment directed at those mechanisms provide an alternative approach to the treatment of patients with ...

We read with great interest the study published by Boxhoorn et al , comparing lumen-apposing metal stents (LAMS) versus double-pigtail plastic stents (DPPS) for treatment of infected necrotising ...

We read with great interest the recent article by Tseng et al evaluating hepatitis B surface antigen (HBsAg) levels as a ...

8 European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain Background Acute-on-chronic liver failure (ACLF) of various aetiologies is a complex syndrome with high ...

The integration of advanced endoscopy within the practice of hepatology is nowadays heralded in the concept of ‘endohepatology’ and is dichotomised in applications intervening for disorders of the ...

Background and aims A previous study of ours indicated that enhancer of zeste homologue 2 (EZH2) plays an important role in hepatocellular carcinoma (HCC) tumorigenesis. The aim of the present study ...

BACKGROUND/AIM Proinflammatory cytokines are key factors in the pathogenesis of Crohn's disease (CD). Activation of nuclear factor kappa B (NFκB), which is involved in their gene transcription, is ...

Background Patients with Inflammatory bowel disease (IBD) have a high prevalence of depression. Gut microbiota dysbiosis has been reported to play an important role in IBD and depression. However, few ...

Liver fibrosis and cirrhosis result from the majority of chronic liver insults and represent a common and difficult clinical challenge of worldwide importance. At present, the only curative treatment ...

Background Anti-tumour necrosis factor α (TNFα) therapy effectively induces and maintains remission in Crohn's disease (CD). Up to 40% of patients, however, fail to respond to anti-TNFα. Objective To ...

The mechanisms of wound healing in general have gained interest in recent years, as it has become obvious that the tightly regulated process of tissue repair and regeneration is of great importance ...