为解决透明细胞肾细胞癌（ccRCC）缺乏有效生物标志物和治疗靶点的问题，研究人员开展了 KIF14 在 ccRCC 中作用的研究。结果显示，KIF14 在 ccRCC 中高表达，与不良预后相关，敲低 KIF14 可抑制细胞增殖。该研究为 ccRCC 治疗提供新方向。

北京大学肿瘤医院内蒙古医院微创介入科等研究机构的研究人员针对这一问题，开展了以 “靶向 NETO2 抑制肝癌细胞增殖、侵袭和迁移并失活 STAT3/C-MYC 通路” 为主题的研究。研究发现，NETO2 敲低能够抑制 HCC 细胞的增殖、侵袭和迁移，同时使 STAT3/C-MYC 通路失活。这一研究结果意义重大，为肝癌的治疗提供了新的潜在靶点，有望改善 HCC ...

In a new study, researchers demonstrate that exosomes can serve as delivery vehicles to introduce AGO2-loaded siRNA into the cytoplasm of bacteria which downregulate gene expression of the mRNA ...

For RT-PCR analysis, we used the Single Cell Sequence Specific Amplification Kit (Vazyme, P621-01) and ChamQ Universal SYBR qPCR Master Mix (Vazyme ... analysis using the Compass for Simple Western ...

Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, ...

State Key Laboratory of Organic−Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China ...

In this study, the authors demonstrated that exosomes can serve as delivery vehicles to introduce AGO2-loaded siRNA into the cytoplasm of bacteria, and in turn down-regulated gene expression of ...

or negative control psl-null siRNA, using 2 μl of X-treme GENE HP DNA transfection reagent (Roche, Germany) following the manufacturer’s protocol for 48 h before cells were subjected to viral ...

In addition, siRNA IL-33 further stimulates LPS enhanced cyclooxygenase-2 (COX-2 ... There were decreased levels of nuclear IL-33 from the TNL to the TL groups, which was consistent with the change ...

For siRNA transfection, cells were plated with 40% confluence in six-well plates ... PAGR1, PGS1 (Figure 1L). However, using qPCR assay, we found that there was no correlation between the mRNA level ...