创新化药指在化学药物研发领域，运用新的化学合成技术、作用靶点发现或新的药物设计理念等，研发出的境内外均未上市的具有全新化学结构和作用机制的化学药品。这类药物通常能治疗现有药物无法有效治疗的疾病，或者在治疗效果、安全性、药代动力学特性等方面较现有药物有 ...

Researchers are enhancing the best features of AAV capsids and overcoming their limitations to accelerate gene-based therapies.

MEG3 directly or competitively binds with miRNA to participate in apoptosis, inflammation ... Bcl-2 overexpression was detected in the siRNA-MEG3 and miR-361–5P inhibitor groups. MEG3 regulates ...

Objective Although the role of microRNA-17 (miR-17) has been identified as a tumour biomarker in various studies, its prognostic value in cancers remains unclear. Therefore, we performed a systematic ...

and the genome-wide screening of siRNA and microRNA libraries to silence most of the genes involved in rotavirus infection will provide insight into the mechanism of entry of these viruses.

PORTLAND, IN, UNITED STATES, January 28, 2025 /EINPresswire / -- The RNA based therapeutics has been explored as a promising treatment option for the diseases which are difficult to treat. Development ...

Various gene silencing technologies like siRNA, miRNA, ribozymes, DNAzymes have shown promise as therapeutics agents against viral diseases. RNAi-based drugs against viruses such as ebola virus ...

Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua ...

Recent progress in high-throughput sequencing has uncovered an astounding landscape of small RNAs in eukaryotic cells. Various small RNAs of distinctive characteristics have been found and can be ...