Results We identified a novel RNA-binding protein, RALY (also known as hnRNPCL2), that is highly associated with colorectal tumour aggressiveness. RALY acts as a key regulatory component in the Drosha ...

Additionally, the study's findings may broadly influence drug discovery efforts targeting RNA-binding proteins. "Our structural insights into ADAR1 provide a solid foundation for designing small ...

RNA metabolism refers to any events in the life cycle of ribonucleic acid (RNA) molecules, including their synthesis, folding/unfolding, modification, processing and degradation. Spliceosomal ...

A comprehensive review titled "From the Test Tube to the Cell: A Homecoming for DNA Computing Circuits?" published Mar. 4 in ...

When the coat proteins come into contact after binding the RNA hairpins, these luciferase fragments, along with the enzyme’s substrate furimazine, join together—and the probe lights up.

"It likely sequesters other RNA-binding proteins, creating an even more toxic environment for cancer cells." Further studies will refine ASO-based therapies and explore their delivery to tumors.

The research work forms the potential basis for more complex RNA machinery. One major challenge in constructing synthetic cells is manufacturing proteins, which are responsible for nearly all ...

(F) The heterotetramer model of Spn-E_RNA_Squ_Tej predicted by AlphaFold3 ... from the AlphaFold2 screening for Piwi-interacting proteins among those encoded by Drosophila genome. (Bi∼ v) The ...

From scathing satires of wealth to murder mysteries set at luxe resorts, these novels are sure to scratch that Mike White itch. By Calum Marsh Katie Kitamura’s thrilling new novel, “Audition ...

Hence, integration of circRNAs with other biomarkers such as proteins and other ... Writing–review and editing. The authors declare that the research was conducted in the absence of any commercial or ...