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The model used a random sequence with noise and an empty protein structure simultaneously but gradually refined the sequence and the structure for more accuracy, better predictions, and lower noise.
In Biology 101, we learn that RNA is a single, ribbon-like strand of base pairs that is copied from our DNA and then read like a recipe to build a protein. But there's more to the story. Some RNA ...
Bridging this gap requires a model that can integrate biological sequence input with structural constraints defined by G4 topological formalism. Objectives of the research: To develop a hybrid AI ...
Figure 1: Cryo-electron microscopic structure of programmed 70S ribosome (RNC) with signal sequence. Figure 3: Transfer of signal sequence from the ribosome to SRP. Figure 4: Mammalian SRP bound ...
Neo-1 is the first model to unify de novo molecular generation and atomic-level structure prediction in a single model, by generating latent representations of whole molecules instead of ...
Scarlett Dvorkin et al Encoding Canonical DNA Quadruplex Structure. Science Advances 4, (2018) eaat3007. Mateus Webba da Silva; (2007) Geometric formalism for DNA quadruplex folding; Chemistry ...