miRNA在癌症中可发挥促癌或抑癌双重作用（如miR-125），其功能取决于肿瘤微环境。循环miRNA通过与外泌体或AGO2蛋白结合保持稳定性，成为理想的液体活检标志物。 循环miRNA作为黑色素瘤诊断标志物 目前黑色素瘤诊断依赖组织病理学评估，但存在24%的诊断分歧率。

然而，肿瘤细胞能够通过多种机制逃避 IFN-γ 介导的免疫激活，导致免疫治疗失败。 Argonaute 2（AGO2）是 Argonaute 家族的关键成员，作为微小 RNA（miRNA）传感器，可对 miRNA 库的动态变化迅速做出反应，并靶向下游 mRNA 发挥多种作用。AGO2 在肿瘤免疫治疗中的作用 ...

RNA-based therapeutics have rapidly emerged over the past decade, offering a new class of medicines that differ significantly from conventional drugs. These therapies can be programmed to target or ...

Elvis Picardo is a regular contributor to Investopedia and has 25+ years of experience as a portfolio manager with diverse capital markets experience. Suzanne is a content marketer, writer, and ...

The brain is a complex organ that controls thought, memory, emotion, touch, motor skills, vision, breathing, temperature, hunger and every process that regulates our body. Together, the brain and ...

The AGO2 protein, an endonuclease, has been reported to colocalize with mitochondria ... to provide novel insight into macrophage differentiation-specific mitomiR signatures and associated ...

This article also discusses the discovery and biogenesis of miRNAs and their relevance to AD. Today’s research continues to add to the wealth of miRNA data that has been accumulated, however, there ...

Because YBX1 is a known RNA binding protein, is secreted by cells in exosomes and physically interacts with miR-223 during the in vitro packaging assay, it met our criteria for a potential exosomal ...

miR-128, a brain-enriched microRNA, has been implicated in the control of neurogenesis and synaptogenesis but its potential roles in intervening processes have not been addressed. We show that ...