In this GEN webinar, Scott Alderucci will discuss ways of leveraging new technologies and experimental design for an optimized, tailored approach to mRNA therapy development.

In this experiment, they ran the TFF at a capacity load of ∼19 g/m 2, less than 2.5 psi trans-membrane pressure, and feed flux of 300 L/m 2 /h (LMH), corresponding to a shear rate of 1594 s −1 ...

The promise of mRNA technology seemed boundless after the success of the coronavirus vaccines, but Robert F. Kennedy Jr. has singled it out for scrutiny, clouding its prospects.

N 6-methyladenosine (m 6 A) affects mRNA processing, translation and decay during cell differentiation, embryonic development and stress responses. Other mRNA modifications — N 1-methyladenosine ...

However, while working in the late Susan Lindquist’s lab at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, Khurana turned up connections to mRNA translation and ...

A new study has been released on the bioRxiv* preprint server, which deals with a comprehensive survey on alternative splicing concerning SARS-CoV-2 infection. This study has also included two ...

mRNA vaccines work differently: The antigen is produced inside the body. The vaccine itself consists of a small piece of genetic code—messenger RNA (mRNA)—to which the immune system responds.

More information: Xue, L., et al. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery, Nature ...

Instead of extracting T-cells and engineering them in a lab, researchers have delivered mRNA directly into circulating immune ...

Transporting mRNA from the nucleus to the cytoplasm, called mRNA export, relies on protein complexes involving RNA helicases such as UAP56. Despite its near-identical nature, URH49 forms a ...

Although the mRNA COVID-19 vaccines from Pfizer-BioNTech and Moderna are safe and effective at preventing severe illness in adults and children, including immunocompromised individuals, researchers ...