想象一下，要在人类30亿个碱基对的基因组中，精确地测试成千上万个单一碱基突变的功能，这无异于大海捞针。传统的实验方法一次只能研究几个突变，效率极低，无法满足大规模筛选的需求。要破解同义突变之谜，首先需要一把能够高效、精准地在基因组上“动手术”的手术刀 ...

2025年6月25日，北京大学化学与分子工程学院的陈鹏团队与生命科学学院的伊成器团队在 Nature上发表了题为“RNA codon expansion via programmable pseudouridine editing and ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

If you're studying genetics, molecular biology or a related field, odds are good that you will need to learn how to read a codon chart (aka codon table) to better understand the genetic code. This ...

This codon optimization can significantly enhance protein expression levels. In addition, researchers are exploring ways to expand the genetic code by assigning new amino acids to certain codons. This ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Codon最初被设计用于基因组学和生物信息学。 Shajii说：“这些领域的数据集越来越大，像Python和R这样的高级语言处理每组测序数据太慢了。 这就是我们想要填补的空白，通过培训一种无需编写C或C++代码即可处理大数据的方法，为不一定是计算机科学家或程序员的领域专家提供帮助。

Alignment and sequencing errors are a major concern in molecular evolution, and this valuable study represents a welcome improvement for genome-wide scans of positive selection. This new method seems ...

The effect of a start codon variant in the LAG3 gene is akin to LAG-3 immune checkpoint inhibitors. Scientists at deCODE genetics, a subsidiary of Amgen, ...

Now, scientists at Scripps Research have designed a new paradigm for easily adding non-canonical amino acids to proteins. Their approach, described in Nature Biotechnologyon September 11, 2024 ...