Glial cells come in many forms, but three major types are currently recognized: astrocytes, oligodendrocytes and microglia. The first are primarily involved in creating the blood-brain barrier and ...

Deletion of the ‘glial cells missing-2’ gene in mice disrupts development of the parathyroid glands but does not eliminate production of parathyroid hormone (PTH), which is required for ...

Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.

Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer's ...

Our Mission: To uncover the mechanisms of glial development & dysfunction & develop breakthrough therapies. Driving a fundamentally different approach to understanding and treating neurological ...

Shihabeddin et al utilized single-cell RNA-Seq analysis of adult P23H zebrafish animals to identify transcription factors (e2fs, Prdm1a, Sp1) expressed selectively in neural progenitors and immature ...

Despite substantial efforts, the molecular mechanisms by which 25-OHC affects glial cells in diseases like amyotrophic lateral sclerosis (ALS) remain unclear. Against this backdrop, a research ...

Michael Barresi’s research interests are focused on how glial cells help wire the nervous system in the embryonic zebrafish brain. His lab discovered that astroglial cells provide a substrate for ...

Glioblastoma multiforme (GBM), commonly referred to as glioblastoma, is a malignant intracranial tumor derived from glial ...

This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...