Department of Medical and Translational Biology, UmeÅ University, 90187 UmeÅ, Sweden Department of Community Medicine and Rehabilitation, Physiotherapy, UmeÅ University, 90187 UmeÅ, Sweden School of ...

本研究针对动脉粥样硬化中血管内皮细胞(VECs)损伤机制不明的关键问题，研究人员揭示了RNA结合蛋白IGF2BP3通过特异性结合乳酸脱氢酶A(LDHA)的3'UTR区域稳定其mRNA，从而逆转氧化低密度脂蛋白(ox-LDL)导致的糖代谢抑制，显著减轻内皮细胞凋亡。该发现为心血管疾病 ...

Deep learning-based in silico modeling (Damayanti et al, 2024) suggested new protein structures and changes in conformation of TFE3 fusion proteins with increased potential for binding DNA, RNA, and ...

This study reports that the RNA binding and cardiomyopathy-associated protein RBM20 is expressed in specific populations of neurons in the CNS, where it binds to and regulates the expression of ...

In preprints that analyzed the genome and the cells of bowhead whales, researchers identified a retroduplication of the gene cyclin-dependent kinase inhibitor 2C (CDKN2C), which regulates the cell ...

vinculin, and also other proteins,” said Sangyoon Han, a mechanobiologist at Michigan Technological University who was not involved in the study. “But not many studies were around to tell if there is ...

On the other hand, existing models extract various features from RNA sequences for prediction and achieve better performance. These methods make predictions at the sequence level, largely ...

We conducted randomization 10 times and took the average number of overlapping target sites. Figure 3. Overlap among RBP binding sites after sequentially removing RBPs with the highest number of ...