Alternatively, he said his research is now exploring other avenues to boost the recruitment of the binding protein 53BP1 to replace the function of alpha-synuclein as a possible treatment for ...

Department of Medical and Translational Biology, UmeÅ University, 90187 UmeÅ, Sweden Department of Community Medicine and Rehabilitation, Physiotherapy, UmeÅ University, 90187 UmeÅ, Sweden School of ...

Scientists have long known that more than 500 genes (out of approximately 20,000 human protein-coding genes) are crucial for DNA repair. By comprehensively analyzing the interactions of these ...

To provide functional insights into m 5 C RNA-modified genes in HEK293T cells, we conducted Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. These results highlighted ...

Transfer RNA-derived small ... with heat shock protein HSPB1 to epigenetically activate MED29 transcription through elevating histone H3K4 monomethylation (H3K4me1) and H3K27 acetylation (H3K27ac) ...

本研究针对动脉粥样硬化中血管内皮细胞(VECs)损伤机制不明的关键问题，研究人员揭示了RNA结合蛋白IGF2BP3通过特异性结合乳酸脱氢酶A(LDHA)的3'UTR区域稳定其mRNA，从而逆转氧化低密度脂蛋白(ox-LDL)导致的糖代谢抑制，显著减轻内皮细胞凋亡。该发现为心血管疾病 ...

1 Laboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, Palaiseau, France 2 Laboratoire de Chimie Moléculaire (LCM), Centre National de ...

Deep learning-based in silico modeling (Damayanti et al, 2024) suggested new protein structures and changes in conformation of TFE3 fusion proteins with increased potential for binding DNA, RNA, and ...