Lipid kinases are enzymes that play a critical role in both cell signalling and membrane trafficking by phosphorylating lipid ...

Lipid kinases are enzymes that play a critical role in both cell signaling and membrane trafficking by phosphorylating lipid ...

Learn more about the research of Mayo Clinic's Gene Editing and Cellular Engineering Laboratory led by David (Chun-Wei) D.

▎药明康德编者按：多肽药物已成为多种疾病的重要治疗模式。今年发表的一篇综述指出，近20年来，FDA批准的多肽药物数目加速上升，显示出这一领域蓬勃发展的趋势。然而，多肽药物开发仍面临体内稳定性不足和细胞渗透性差等挑战，需通过多种工程化改造手段提升其成药 ...

Breast cancer is the most commonly diagnosed cancer among women worldwide and represents a major public health concern due to ...

A recent study published in Genes & Diseases reveals a novel role of XPR1 in promoting ovarian cancer growth by regulating ...

The New England Patriots continue to make adjustments to their defensive front.

Potential Best-In-Class Bispecific Antibody ATI-052 Targets Both Thymic Stromal Lymphopoietin (TSLP) and Interleukin-4 ...

We found that accumulation of K63 ubiquitin chains in damaged lysosomes activates the TAB–TAK1–IKK–NF-κB pathway, which in turn induces the expression of various transcription factors and cytokines.

In this study, we unravel the biased signal transduction pathway mediated by a reported partial G i -protein-biased APLNR agonist CMF-019 and developed a biased chemical space remodeling approach to ...

Their findings on this mechano-transduction pathway involving TRPV4 channels, calcium homeostasis, cell volume plasticity, motility and invasiveness will have a great impact in the cancer field and ...